J.D. Salinger, on the astonishing popularity of his slender ouevre:
I can't explain why [it] caught on the way it did, and I don't think I could ever duplicate it. A lot of things have to go right all at once.
Oh, wait. That's not Salinger; it's the reclusive Bill Watterson, summing up his thoughts on Calvin & Hobbes in his first interview in 15 years, here.